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Pressbox (Press Release) - Renal and scar volumes and pathology were compared after scanning and killing. Of the 48 points of injury, 40 (83%) in the 16 rats were detected grossly. Under microscopy, 36 injuries (75%) were detected on mid-kidney cross-sections. The average lesion was 4.2 mm3 corresponding to 0.5% of the kidney volume. Using pathological findings as the gold standard, the sensitivity and specificity of scar detection using MRI was 69% and 93%, respectively. A rat model was created to demonstrate the sensitivity of dynamic contrast-enhanced MRI for detecting renal scars. Alcohol and electrocautery created reliable renal scars that were confirmed pathologically. MRI detected these lesions that averaged 4.2 mm3 (0.5% total renal volume) with sensitivity and specificity of 69% and 93%, respectively. J. Magn. Reson. Imaging 2010;31:1132�C1136. ? 2010 Wiley-Liss, Inc. ""To develop a reproducible small-animal dynamic contrast-enhanced www.selleckchem.com (DCE) MRI set-up for mice through which volumes <100 ��L can be accurately and safely injected and to test this set-up by means of DCE measurements in resting muscle and tumor tissue. The contrast agent (CA) injection system comprised 2 MR-compatible syringe SB-203580 pumps placed 50 cm from the 7T magnet bore where the fringe field is approximately 40 mT. Microbore tubing and T-connector, close to the injection site, minimized dead volume (<10 ��L). For DCE-MRI measurements in 8 CB-17 SCID mice with 1500�C2500 mm3 large orthotopic neuroblastoma, a bolus of 10-fold-diluted this website Gd-DTPA CA solution (0.1 mmol/kg) was delivered (5 ��L/s), followed by a 50-��L saline flush. Retro-orbital injections were given instead of tail vein injections, because the peripheral vasculature was reduced because of large tumor burden. The CA injection was successful in 19 of 24 experiments. Optical assessment showed minimal dispersion of ink-colored CA bolus. Mean (��SD) pharmacokinetic parameters retrieved from DCE-MRI examinations in resting muscle (Ktrans = 0.038 �� 0.025 min?1, kep = 0.66 �� 0.48 min?1, ve = 0.060 �� 0.014, vp = 0.033 �� 0.021) and tumor (Ktrans = 0.082 �� 0.071 min?1, kep = 0.82 �� 0.80 min?1, ve = 0.121 �� 0.075, vp = 0.093 �� 0.051) agreed with those reported previously. We successfully designed and implemented a DCE-MRI set-up system with short injection lines and low dead volume. The system can be used at any field strength with the syringe pumps placed at a sufficiently low fringe field (<40 mT). J. Magn. Reson. Imaging 2013;37:746�C751. ? 2012 Wiley Periodicals, Inc. ""To determine the effectiveness of MR angiography for pulmonary embolism (MRA-PE) in symptomatic patients. We retrospectively reviewed all patients whom were evaluated for possible pulmonary embolism (PE) using MRA-PE. A 3-month and 1-year from MRA-PE electronic medical record (EMR) review was performed. Evidence for venous thromboembolism (VTE) (or death from PE) within the year of follow-up was the outcome surrogate for this study.Submitted by: