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The 18S assays were run at the beginning and in the middle of assays, to verify the integrity of the samples. Statistical analysis of the qPCR results was performed by paired t-test. Significance for all tests was assumed at the level of P <0.05 (*P <0.05; **P <0.001; ***P <0.0001). We thank Drs(Added: Sat Jun 02 2018)

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